The　isolated　integrated　energy　system　coupled　with　multiple　types　of　energy　systems　is　one　of　the　important　ways　to　guarantee　the　quality　of　energy　use　in　remote　areas,　but　due　to　the　lack　of　external　main　network＇s　support　and　random　renewable　energy　output,　there　is　a　greater　risk　of　load　cutting,　which　puts　forward　higher　requirements　for　the　operation　optimization　of　the　isolated　integrated　energy　system.　Therefore,　this　paper　first　constructs　a　two-stage　optimization　model　from　both　supply　and　demand　side　for　the　linkage　development　of　resources　within　the　isolated　integrated　energy　system.　Secondly,　an　evaluation　index　system　containing　economic　benefits　and　system　efficiency　is　constructed　to　quantify　the　comprehensive　benefits　of　the　two-stage　operation　optimization.　Finally,　a　remote　area　in　China　is　selected　as　the　research　background　for　example　analysis.　The　results　show　that　(1)　Due　to　the　low　matching　between　supply　and　demand　of　the　isolated　integrated　energy　system,　the　unit　operation　optimization　is　only　conducted　from　the　energy　supply　side,　and　the　total　load　shedding　is　about　101.402　MW.　(2)　Considering　the　load　side　optimization　in　the　first　stage,　the　demand　side　resources　can　be　mobilized　to　improve　the　supply　and　demand　matching　degree.　Compared　with　the　second　stage　optimization　in　Scenario　1,　the　internal　supply　rates　in　Scenarios　2,　3　and　4　are　increased　by　0.399,　0.159　and　0.567　respectively,　and　the　system　net　income　is　increased　by　8990,　18840　and　2310　CNY　respectively.　Limited　by　factors,　such　as　the　subsidy　price　on　the　load　side,　the　demand　elasticity　matrix　and　the　energy　selling　price　on　the　energy　supply　side,　there　is　no　negative　linear　relationship　between　the　amount　of　load　shedding　and　the　improvement　of　energy　supplier＇s　economic　benefits,　so　it　is　necessary　to　consider　actual　operation　scenarios　and　reasonably　arrange　operation　and　dispatching　plans.(c)　2022　The　Authors.　Published　by　Elsevier　Ltd.　This　is　an　open　access　article　under　the　CC　BY-NC-ND　license　(http://creativecommons.org/licenses/by-nc-nd/4.0/).