Per-　and　polyfluoroalkyl　substances　(PFASs)　are　a　class　of　highly　fluorinated　aliphatic　compounds　that　are　persistent　and　bioaccumulate,　posing　a　potential　threat　to　the　aquatic　environment.　The　electroplating　industry　is　considered　to　be　an　important　source　of　PFASs.　Due　to　emerging　PFASs　and　many　alternatives,　the　acute　toxicity　data　for　PFASs　and　their　alternatives　are　relatively　limited.　In　this　study,　a　QSAR-ICE-SSD　composite　model　was　constructed　by　combining　quantitative　structure-activity　relationship　(QSAR),　interspecies　correlation　estimation　(ICE),　and　species　sensitivity　distribution　(SSD)　models　in　order　to　obtain　the　predicted　no-effect　concentrations　(PNECs)　of　selected　PFASs.　The　PNECs　for　the　selected　PFASs　ranged　from　0.254　to　6.27　mg/L.　The　sigma　PFAS　concentrations　ranged　from　177　to　983　ng/L　in　a　river　close　to　an　electroplating　industry　in　Shenzhen.　The　ecological　risks　associated　with　PFASs　in　the　river　were　below　2.97　x　10(-4).