In　order　to　study　the　seismic　response　of　buried　pipeline　under　non-uniforn　excitation,　this　paper　presents　a　three-dimensional　(3D)　finite　element　numerical　model　based　on　the　shaking　table　test　of　a　buried　pipeline　under　nonuniform　excitation,　which　considers　the　nonuniform　seismic　excitation　and　pipe-soil　nonlinear　dynamic　interaction　of　the　buried　pipeline.　The　model　adopts　the　static　and　dynamic　coupling　analysis　method,　and　Davidenkov　nonlinear　constitutive　model　was　utilized　for　the　soil　analysis.　The　pipe-soil　interaction　adopts　frictional　contact　to　consider　the　slip　and　separation　of　the　pipe　and　soil.　The　roller　boundary　is　adopted　in　the　model.　The　input　of　the　numerical　model　is　the　acceleration　time　history　measured　at　the　bottom　of　the　corresponding　active　box　in　the　shaking　table　tests.　The　analysis　results　show　that　the　numerical　simulation　results　fit　well　with　the　measured　results　of　the　shaking　table　tests　in　terms　of　the　acceleration　time　history,　acceleration　amplification　coefficient,　and　strain　peak　curve　along　the　axial　direction　of　the　pipeline,　reflecting　similar　laws,　which　mutually　confirms　the　correctness　of　the　numerical　model　and　shaking　table　test　results.　©　2023　Editorial　Board　of　Journal　of　Harbin　Engineering.　All　rights　reserved.