The　very　high　cycle　fatigue　crack　initiation　mechanism　of　Ti60　titanium　alloy　at　different　temperatures　was　studied.　The　results　showed　that　the　initiation　of　cracks　occurred　on　oversized　facets　in　the　subsurface.　Based　on　this　crack　initiation　mechanism,　a　full-life　prediction　model　based　on　crack　propagation　at　room　temperature　was　first　proposed,　and　then　a　very　high　cycle　fatigue　life　prediction　model　considering　temperature　was　proposed　based　on　the　degradation　law　of　tensile　strength　at　different　temperatures.　The　experimental　and　predicted　life　results　of　Ti60　specimen　at　room　temperature　with　300　degrees　C　and　500　degrees　C　showed　that　the　proposed　method　can　effectively　predict　the　very　high　cycle　fatigue　life,　and　the　error　is　within　a　factor　of　3.