The　classical　groundwater　seepage　theory　was　established　on　the　basis　of　the　principle　of　water　equilibrium,　which　cannot　explain　the　phenomenon　of　well　water　level　change　caused　by　natural　seismic　activities　and　other　external　loads,　and　is　not　conducive　to　the　in-depth　understanding　of　the　role　of　groundwater　seepage　movement　in　various　environmental　geological　disasters.　To　solve　this　problem,　a　mathematical　model　of　pore　pressure　change　of　a　confined　aquifer　driven　by　seismic　wave　stress　is　constructed　based　on　the　fluid-structure　coupling　dynamic　theory.　The　numerical　verification　of　the　model　is　realized　by　using　the　software　Comsol.　The　change　characteristics　of　well　water　level　are　inversely　performed　by　using　the　Cooper　theory,　and　the　results　are　compared　with　the　change　characteristics　of　well　water　level　caused　by　strong　earthquakes　in　the　Sichian-Yunnan　region.　The　influencing　factors　of　seepage　movement　of　a　confined　aquifer　under　earthquake　are　studied　by　changing　the　simulation　parameters.　The　results　show　that　when　seismic　wave　loads　act　on　the　confined　aquifers,　pore　pressure　oscillates　in　the　same　period　as　the　seismic　waves,　and　the　amplitude,　frequency　and　hydraulic　slope　of　the　seismic　waves　have　significant　effects　on　the　pore　pressure,　while　the　coefficient　of　permeability　and　porosity　have　little　effect　on　the　change　characteristics.　At　the　initial　stage　of　seismic　wave　loading,　pore　pressure　increases　rapidly,　and　then　part　of　the　water　in　the　aquifer　is　slowly　discharged.　The　load　pressure　gradually　transfers　to　the　granular　framework,　and　the　rate　of　change　of　pore　pressure　slows　down　and　tends　to　reach　a　new　equilibrium.　The　variation　characteristics　of　well　water　level　are　closely　related　to　pore　pressure,　and　the　oscillation　period　and　variation　pattern　are　consistent　with　pore　pressure,　but　the　amplitude　is　different.　Generally,　the　oscillation　rises　and　tends　to　be　stable,　which　is　basically　the　same　with　the　variation　pattern　of　well　water　level　observed　in　the　Sichuan-Yunnan　region.　The　results　are　of　valuable　exploration　significance　for　the　establishment　and　improvement　of　groundwater　seepage　theory　under　stress,　and　can　enrich　and　expand　the　research　ideas　and　application　fields　of　traditional　groundwater　dynamics　and　classical　fluid-structure　coupling　theory.　©　2023　Editorial　Office　of　Hydrogeology　and　Engineering