By　the　end　of　2021,　over　273　million　people　have　been　infected　with　SARS-CoV-2.　Many　nonpharmaceutical　interventions　(NPI)　have　been　commonly　used　to　control　the　COVID-19.　However,　if　such　interventions　were　implemented　during　the　stable　period　of　the　epidemic,　it　would　waste　unnecessary　energy.　Therefore,　it　is　crucial　to　find　a　strategy　on　COVID-19　prevention　and　control　according　to　the　balance　between　infection　risk　and　energy　consumption.　Long-range　airborne　transmission　is　one　of　the　most　important　routes　the　spread　of　COVID-19.　Considering　the　personnel　metabolism　and　dynamic　quanta　generation　in　four　indoor　environments　(home,　office,　classroom,　subway),　we　established　the　infection　risk-energy　consumption　model.　After　optimization,　compared　with　the　intervention　of　maximizing　the　fresh　air　volume　in　each　indoor　environment,　energy　consumption　of　homes,　offices,　classrooms　and　subways　were　reduced　by　44.7%,　25.9%,　28.7%　and　14.7%　respectively　in　summer　and　47.8%,　40.7%,　42.　1%　and　21.2%　respectively　in　winter.　©　2023,　The　Author(s),　under　exclusive　license　to　Springer　Nature　Singapore　Pte　Ltd.