The　COVID-19　pandemic　threatened　the　world.　As　an　important　transportation　hub　connecting　countries　and　regions,　airports　have　played　a　critical　role　in　COVID-19　prevention　and　control.　This　study　developed　an　infection　risk-human　comfort-energy　consumption　model　to　calculate　the　COVID-19　transmission　and　energy　consumption　for　epidemic　prevention　and　control　in　seven　different　functional　areas　of　an　airport　during　different　seasons　(winter,　summer,　and　transition　season)　and　actual　passenger　movement.　When　considering　dynamic　passenger　flow,　the　energy　consumption　needed　to　prevent　and　control　transmission　of　the　epidemic　in　each　area　of　the　airport　could　be　reduced　by　71–85　%.　The　waiting,　dining,　and　shopping　areas　were　the　areas　with　the　highest　energy　consumption,　accounting　for　25–47　%,　15–32　%,　and　11–38　%　of　the　total　energy　consumption　of　epidemic　prevention　at　the　airport,　respectively.　The　dining　area　had　the　highest　energy　consumption　per　square　meter,　reaching　14.2　kWh/m2　at　its　highest.　After　closing　the　dining　area,　energy　consumption　was　reduced　by　14–20　%.　Compared　with　strict　epidemic　prevention　and　control,　energy　consumption　in　the　airport　was　reduced　by　70–85　%　considering　both　optimized　intervention　and　dynamic　passenger　flow.　The　results　of　this　study　provide　a　scientific　basis　for　energy-saving　and　emission　reduction　in　airports　under　an　epidemic　situation.　©　2024