Objective　To　investigate　the　hemodynamic　effects　of　enhanced　external　counterpulsation　(EECP)　on　cerebral　arteries　with　different　stenoses.　Methods　Zero-dimensional/　three-dimensional　multiscale　hemodynamic　models　of　cerebral　arteries　with　different　stenoses　were　constructed.　Numerical　simulations　of　the　EECP　hemodynamics　were　performed　under　different　counterpulsation　modes　to　quantify　several　hemodynamic　indicators　of　the　cerebral　arteries.　Among　them,　the　mean　time-averaged　wall　shear　stress　(TAWSS)　downstream　of　the　stenosis　was　in　the　range　of　4-7　Pa,　a　low　percentage　of　TAWSS　risk　area,　and　high　narrow　branch　flow　were　considered　to　inhibit　the　development　of　atherosclerosis　and　create　a　good　hemodynamic　environment.　Results　For　cerebral　arteries　with　50%,　60%,　70%,　and　80%　stenosis,　the　hemodynamic　environment　was　optimal　in　counterpulsation　mode　when　the　moment　of　cuff　deflation　was　0.　5,　0.　6,　0.　7,　and　0.　7　s　within　the　cardiac　cycle.　Conclusions　For　50%　stenotic　cerebral　arteries,　the　counterpulsation　mode　with　a　deflation　moment　of　0.　5　s　should　be　selected.　For　60%　stenotic　cerebral　arteries,　the　counterpulsation　mode　with　a　deflation　moment　of　0.　6　s　should　be　selected.　For　70%　or　80%　stenotic　cerebral　arteries,　the　counterpulsation　mode　with　a　deflation　moment　of　0.　7　s　should　be　selected.　As　stenosis　of　the　cerebral　arteries　increases,　the　pressure　duration　should　be　prolonged.　This　study　provides　a　theoretical　reference　for　the　EECP　treatment　strategy　for　patients　with　ischemic　stroke　with　different　stenoses.　©　2024　Editorial　Department　of　Journal　of　Shanghai　Second　Medical　University.　All　rights　reserved.