A　reinforced　concrete　(RC)　frame　structure　is　one　of　the　widely　used　structural　system.　A　localized　damage　caused　by　extreme　events　may　lead　to　progressive　collapse　of　entire　structures.　In　this　paper,　progressive　collapse　test　of　three　1/3-scaled　reinforced　concrete　frame,　including　a　single-story　without　a　slab,　single-story　with　a　slab,　and　double-story　with　slabs,　are　reported.　Experimental　results　show　that　the　progressive　collapse　process　of　RC　frame　consisted　of　five　stages:　an　elastic　stage,　yield　stage,　beam　mechanism　stage,　transient　stage　and　catenary　stage.　The　reinforced　concrete　slabs　contribute　to　large　progressive　collapse　resistance　force　compared　with　the　specimen　without　slab.　Furthermore,　validation　of　the　test　results　by　using　a　refined　solid　finite　element　model　was　established.　The　effect　of　extensive　parameters,　including　slab　thickness,　beam　section　height,　seismic　design　intensity,　and　so　forth,　on　the　progressive　collapse　performance　of　RC　frame　structures　was　simulated　as　well.　The　simulation　results　indicated　that　the　collapse　resistance　of　RC　structures　was　substantially　improved　with　the　increased　of　the　slab　thickness　and　seismic　design　intensity.　Finally,　a　simplified　model　is　proposed　in　accordance　with　experimental　and　numerical　results　to　calculate　the　collapse　resistance　of　RC　frame　structures.