Electronic　waste　dismantling　has　induced　the　surrounding　agricultural　soils　suffered　from　combined　contamination　of　heavy　metals　and　organic　pollutants.　Lower　efficiency　and　complex　mechanisms　of　bioremediation　remain　to　be　resolved.　Here,　we　adopted　regulations　to　Sedum　plumbizincicola　cross　aboveground　and　below-　ground　scales　to　strengthen　the　bioremediation　efficiency.　Results　showed　that　the　S.　plumbizincicola　inter-　cropping　with　the　Astragalus　sinicus　L　.　that　inoculated　with　Rhizobium　had　the　highest　performance　in　reductions　of　Cd,　PBDEs　and　PCBs　from　soils　by　0.11　mg/kg,　67.93　mu　g/kg　and　38.91　mu　g/kg,　respectively.　Rhizosphere　soil　metabolomics　analysis　demonstrated　that　reductions　in　Cd　and　PBDEs　significantly　associated　with　2-Methylhippuric　acid　and　L-Saccharopine,　which　were　involved　in　phenylalanine　metabolism,　biosynthesis　of　amino　acids　and　lysine.　Metagenomics　analysis　revealed　that　these　functional　pathways　were　mediated　by　Frankia,　Mycobacterium,　Blastococcus,　etc.　microbial　taxa,　which　were　also　significantly　altered　by　regulations.　Moreover,　regulation　regimes　significantly　affected　transcription　genes　of　S.　plumbizincicola.　Functional　annotation　revealed　that　cross-scale　regulations　significantly　improved　bioremediation　efficiency　through　microorganisms　and　metabolites　in　the　rhizosphere　and　transcription　genes　of　S.　plumbizincicola,　which　were　illustrated　to　promote　plant　growth　and　tolerance　to　environmental　stress.　Our　integration　of　multi-omics　provides　comprehensive　and　deep　insights　into　molecular　mechanisms　in　the　cross-scale　regulations　of　S.　plumbizincicola,　which　would　favor　remediation　techniques　advances　for　the　soil　contaminated　by　electronic　waste　dismantling.