Rational　regulation　of　interface　structure　in　photocatalysts　is　a　promising　strategy　to　improve　the　photocatalytic　performance　of　carbon　dioxide　(CO2)　reduction.　However,　it　remains　a　challenge　to　modulate　the　interface　structure　of　multi-component　heterojunctions.　Herein,　a　strategy　integrating　heterojunction　with　facet　engineering　is　developed　to　modulate　the　interface　structure　of　metal-organic　frameworks　(MOF)-based　heterojunctions.　A　series　of　core-shell　UiO-66　(Zr-MOF)-loaded　MIL-125　(Ti-MOF)　heterojunctions　with　exposed　specific　facets　were　prepared　to　enhance　the　separation　efficiency　of　photogenerated　electrons-holes　in　CO2　photoreduction.　Impressively,　MIL-125to@UiO-66　with　exposed　{1　1　1}　facet　exhibits　an　excellent　CO　production　rate　(56.4　mu　mol　g-　1　h-　1)　and　selectivity　(99　%)　under　visible　light　irradiation　without　any　photosensitizers/　sacrificial　agents,　being　1.4　and　11.3　times　higher　than　individual　MIL-125to　and　UiO-66,　respectively.　The　typeII　heterojunction　significantly　enhances　the　separation　of　photogenerated　electrons-holes　in　physical　space.　The　photogenerated　electrons　migrate　from　Zr　in　UiO-66　to　Ti　in　MIL-125to,　promoting　a　spatial　synergy　between　CO2　reduction　on　MIL-125to　and　H2O　oxidation　on　UiO-66.　Compared　with　MIL-125rd@UiO-66　with　exposed　{1　1　0}　facet　and　MIL-125ds@UiO-66　with　exposed　{0　0　1}　facet,　MIL-125to@UiO-66　with　exposed　{1　1　1}　facet　improves　the　exposure　of　surface-active　Ti　sites,　thereby　enhancing　the　adsorption/activation　of　CO2　to　generate　the　*COOH　intermediate.　This　work　provides　an　effective　strategy　for　designing　MOF-based　heterojunction　photocatalysts　to　improve　photocatalytic　performance.