Phthalates　(PAEs)　constitute　the　primary　components　of　indoor　dust　pollutants　and　significantly　impact　human　reproductive　health.　However,　research　on　novel　alternatives　to　PAEs　and　the　risk　assessment　of　mixed　exposure　has　remained　relatively　sparse.　In　this　study,　193　indoor　dust　samples　were　collected　in　2022　from　various　campus　locations,　including　classrooms,　canteens,　dormitories,　offices,　and　laboratories.　Forty-four　traditional　PAEs　and　their　alternatives　were　identified,　with　concentrations　ranging　from　0.44　to　91.5　mu　g/g.　Di(2-ethylhexyl)　phthalate　(DEHP)　and　dioctyl　terephthalate　(DEHTH)　were　the　predominant　compounds,　with　mean　concentrations　of　86.3　and　59.2　mu　g/g,　respectively.　The　ingestion　pathway　was　the　principal　route　of　exposure,　with　dormitories　identified　as　the　primary　exposure　sites.　The　mixed　reproductive　toxicity　equivalent　factor　(TEFmix)　of　PAEs　and　their　alternatives　was　developed　using　a　quantitative　structure-activity　relationship　(QSAR)　model　in　conjunction　with　machine　learning　algorithms.　The　TEFmix　was　found　to　be　lower　than　the　sum　of　individual　PAEs,　potentially　due　to　the　antagonistic　effects　of　PAE　monomers　on　reproductive　health.　Under　high-exposure　scenarios,　the　TEFmix　of　PAEs　in　canteen　dust　was　determined　to　be　0.245,　surpassing　values　observed　in　other　environments.　Females　exhibited　a　higher　risk,　with　dormitories　presenting　a　greater　exposure　risk　than　those　in　other　indoor　locations.　This　study　provided　essential　data　to　inform　regulatory　measures　aimed　at　mitigating　the　impact　of　PAEs　and　their　alternatives　in　indoor　dust　on　human　reproductive　health.