This　study　developed　manganese-based　oxide　(MnOx)　catalysts　using　a　mechanochemical　oxidation　method　at　room　temperature,　employing　a　metal-organic　framework　(Mn-BTC)　as　the　precursor　and　KMnO4　as　the　oxidizing　agent.　Among　the　synthesized　catalysts,　MnOx-0.2　demonstrated　the　highest　catalytic　activity　for　propane　oxidation,　achieving　a　low　T90　temperature　of　only　238　°C.　Comprehensive　characterization　revealed　that　the　MnOx-0.2　catalyst　possessed　a　distinctive　nanowire　structure,　abundant　oxygen　vacancies,　a　significantly　increased　surface-active　oxygen-to-lattice　oxygen　ratio　(Osur/Olatt　=　1.904),　and　a　higher　Mn3+　content　(51.76　%).　These　unique　properties　significantly　enhanced　lattice　oxygen　mobility　and　redox　capability.　Furthermore,　in　situ　DRIFTS　studies　demonstrated　that　the　cooperative　interaction　between　surface-active　oxygen　species　and　lattice　oxygen　effectively　facilitated　the　catalytic　oxidation　reaction.　This　research　provides　a　simple,　efficient,　and　environmentally　friendly　strategy　for　synthesizing　high-performance　MnOx　catalysts　with　promising　potential　for　practical　industrial　applications.　©　2025