The　effect　of　CO2　laser　irradiation　on　the　La0.67Ca0.33MnO3　(LCMO)　thin　film　was　studied.　The　epitaxial　thin　films　were　prepared　on　single　crystal　SrTiO3　(001)　substrates　by　pulsed　laser　deposition　and　irradiated　for　10-60　seconds　in　air　by　using　CO2　laser.　The　crystallinity　of　LCMO　thin　films　were　strongly　enhanced　by　CO2　laser　irradiation.　It　is　found　that　CO2　laser　irradiation　results　in　a　dramatic　decrease　in　the　resistivity　and　remarkable　increases　in　the　insulator-metal　transition　temperature　(Tp)　and　the　temperature　coefficient　of　resistance　TCR.　The　significant　improvements　of　the　structure　and　transport　are　achieved　in　several　dozens　of　seconds,　which　suggests　that　CO2　laser　irradiation　can　be　utilized　to　tune　CMR　manganites　both　fast　and　effectively　for　industrial　applications.