The　Fe-modified　sepiolite-supported　Mn-Cu　mixed　oxide　(CuxMny/Fe-Sep)　catalysts　were　prepared　using　the　co-precipitation　method.　These　materials　were　characterized　by　means　of　the　XRD,　N-2　adsorption-desorption,　XPS,　H-2-TPR,　and　O-2-TPD　techniques,　and　their　catalytic　activities　for　CO　and　ethyl　acetate　oxidation　were　evaluated.　The　results　show　that　catalytic　activities　of　the　CuxMny/Fe-Sep　samples　were　higher　than　those　of　the　Cu1/Fe-Sep　and　Mn2/Fe-Sep　samples,　and　the　Mn/Cu　molar　ratio　had　a　distinct　influence　on　catalytic　activity　of　the　sample.　Among　the　CuxMny/Fe-Sep　and　Cu1Mn2/Sep　samples,　Cu1Mn2/Fe-Sep　performed　the　best　for　CO　and　ethyl　acetate　oxidation,　showing　the　highest　reaction　rate　and　the　lowest　T-50　and　T-90　of　4.4　x　10(-6)　mmol.g(-1).s(-1),　110,　and　140　degrees　C　for　CO　oxidation,　and　1.9　x　10(-6)　mmol.g(-1).s(-1),　170,　and　210　degrees　C　for　ethyl　acetate　oxidation,　respectively.　Moreover,　the　Cu1Mn2/Fe-Sep　sample　possessed　the　best　low-temperature　reducibility　and　the　lowest　temperature　of　oxygen　desorption　as　well　as　the　highest　surface　Mn4+/Mn3+　and　Cu2+/CuO　atomic　ratios.　It　is　concluded　that　factors,　such　as　the　strong　interaction　between　the　Cu　or　Mn　and　the　Fe-Sep　support,　good　low-temperature　reducibility,　and　good　mobility　of　chemisorbed　oxygen　species,　might　account　for　the　excellent　catalytic　activity　of　Cu1Mn2/Fe-Sep.　(C)　2017　The　Chemical　Industry　and　Engineering　Society　of　China,　and　Chemical　Industry　Press.　All　rights　reserved.