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Author:

Chen, Jie (Chen, Jie.) | Liu, Cheng-Fu (Liu, Cheng-Fu.) | Yang, Cheng-Wen (Yang, Cheng-Wen.) | Zeng, Cheng-Chu (Zeng, Cheng-Chu.) (Scholars:曾程初) | Liu, Wei (Liu, Wei.) | Hu, Li-Ming (Hu, Li-Ming.) (Scholars:胡利明)

Indexed by:

Scopus SCIE

Abstract:

A series of potential HIV-1 integrase inhibitors based on 5-chloro-2-hydroxy-3-triazolylbenzoic acid scaffold was designed and synthesized. Some of these compounds exhibit potent inhibitory activities at micromolar concentrations against HIV-1 integrase in the 3'-end processing and the strand transfer step.

Keyword:

2-Hydroxy-3-triazolylbenzoic acids HIV IN inhibitors Metal ion binding Diketo acids Click chemistry

Author Community:

  • [ 1 ] [Chen, Jie]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 2 ] [Liu, Cheng-Fu]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 3 ] [Yang, Cheng-Wen]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 4 ] [Zeng, Cheng-Chu]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 5 ] [Liu, Wei]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 6 ] [Hu, Li-Ming]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China

Reprint Author's Address:

  • 曾程初

    [Zeng, Cheng-Chu]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China

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Source :

MEDICINAL CHEMISTRY RESEARCH

ISSN: 1054-2523

Year: 2015

Issue: 7

Volume: 24

Page: 2950-2959

2 . 6 0 0

JCR@2022

ESI Discipline: PHARMACOLOGY & TOXICOLOGY;

ESI HC Threshold:182

JCR Journal Grade:3

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 3

SCOPUS Cited Count: 4

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 8

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