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Author:

Rong, Lu (Rong, Lu.) (Scholars:戎路) | Latychevskaia, Tatiana (Latychevskaia, Tatiana.) | Chen, Chunhai (Chen, Chunhai.) | Wang, Dayong (Wang, Dayong.) (Scholars:王大勇) | Yu, Zhengping (Yu, Zhengping.) | Zhou, Xun (Zhou, Xun.) | Li, Zeyu (Li, Zeyu.) | Huang, Haochong (Huang, Haochong.) | Wang, Yunxin (Wang, Yunxin.) (Scholars:王云新) | Zhou, Zhou (Zhou, Zhou.)

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Scopus SCIE PubMed

Abstract:

Terahertz waves provide a better contrast in imaging soft biomedical tissues than X-rays, and unlike X-rays, they cause no ionisation damage, making them a good option for biomedical imaging. Terahertz absorption imaging has conventionally been used for cancer diagnosis. However, the absorption properties of a cancerous sample are influenced by two opposing factors: an increase in absorption due to a higher degree of hydration and a decrease in absorption due to structural changes. It is therefore difficult to diagnose cancer from an absorption image. Phase imaging can thus be critical for diagnostics. We demonstrate imaging of the absorption and phase-shift distributions of 3.2 mm x 2.3 mm x 30-mu m-thick human hepatocellular carcinoma tissue by continuous-wave terahertz digital in-line holography. The acquisition time of a few seconds for a single in-line hologram is much shorter than that of other terahertz diagnostic techniques, and future detectors will allow acquisition of meaningful holograms without sample dehydration. The resolution of the reconstructions was enhanced by sub-pixel shifting and extrapolation. Another advantage of this technique is its relaxed minimal sample size limitation. The fibrosis indicated in the phase distribution demonstrates the potential of terahertz holographic imaging to obtain a more objective, early diagnosis of cancer.

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Author Community:

  • [ 1 ] [Rong, Lu]Beijing Univ Technol, Coll Appl Sci, Beijing 100124, Peoples R China
  • [ 2 ] [Wang, Dayong]Beijing Univ Technol, Coll Appl Sci, Beijing 100124, Peoples R China
  • [ 3 ] [Huang, Haochong]Beijing Univ Technol, Coll Appl Sci, Beijing 100124, Peoples R China
  • [ 4 ] [Wang, Yunxin]Beijing Univ Technol, Coll Appl Sci, Beijing 100124, Peoples R China
  • [ 5 ] [Latychevskaia, Tatiana]Univ Zurich, Dept Phys, CH-8057 Zurich, Switzerland
  • [ 6 ] [Zhou, Xun]CAEP, Res Ctr Laser Fus, Mianyang 621900, Peoples R China
  • [ 7 ] [Li, Zeyu]CAEP, Res Ctr Laser Fus, Mianyang 621900, Peoples R China
  • [ 8 ] [Zhou, Xun]CAEP, Terahertz Res Ctr, Mianyang 621900, Peoples R China
  • [ 9 ] [Li, Zeyu]CAEP, Terahertz Res Ctr, Mianyang 621900, Peoples R China
  • [ 10 ] [Chen, Chunhai]Third Mil Med Univ, Dept Occupat Hlth, Chongqing 400038, Peoples R China
  • [ 11 ] [Yu, Zhengping]Third Mil Med Univ, Dept Occupat Hlth, Chongqing 400038, Peoples R China
  • [ 12 ] [Zhou, Zhou]Third Mil Med Univ, Dept Occupat Hlth, Chongqing 400038, Peoples R China

Reprint Author's Address:

  • [Zhou, Xun]Beijing Univ Technol, Coll Appl Sci, 100 Pingleyuan Rd, Beijing 100124, Peoples R China

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Source :

SCIENTIFIC REPORTS

ISSN: 2045-2322

Year: 2015

Volume: 5

4 . 6 0 0

JCR@2022

ESI Discipline: Multidisciplinary;

ESI HC Threshold:464

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count: 145

SCOPUS Cited Count: 151

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 8

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