Purpose:　Previous　studies　have　shown　brain　reorganizations　after　early　deprivation　of　auditory　sensory.　However,　changes　of　grey　matter　connectivity　have　not　been　investigated　in　prelingually　deaf　adolescents　yet.　In　the　present　study,　we　aimed　to　investigate　changes　of　grey　matter　connectivity　within　and　between　auditory,　language　and　visual　systems　in　prelingually　deaf　adolescents.　Methods:　We　recruited　16　prelingually　deaf　adolescents　and　16　age-　and　gender-matched　normal　controls,　and　extracted　the　grey　matter　volume　as　the　structural　characteristic　from　14　regions　of　interest　involved　in　auditory,　language　or　visual　processing　to　investigate　the　changes　of　grey　matter　connectivity　within　and　between　auditory,　language　and　visual　systems.　Sparse　inverse　covariance　estimation　(SICE)　was　utilized　to　construct　grey　matter　connectivity　between　these　brain　regions.　Results:　The　results　show　that　prelingually　deaf　adolescents　present　weaker　grey　matter　connectivity　within　auditory　and　visual　systems,　and　connectivity　between　language　and　visual　systems　declined.　Notably,　significantly　increased　brain　connectivity　was　found　between　auditory　and　visual　systems　in　prelingually　deaf　adolescents.　Conclusions:　Our　results　indicate　＂cross-modal＂　plasticity　after　deprivation　of　the　auditory　input　in　prelingually　deaf　adolescents,　especially　between　auditory　and　visual　systems.　Besides,　auditory　deprivation　and　visual　deficits　might　affect　the　connectivity　pattern　within　language　and　visual　systems　in　prelingually　deaf　adolescents.