Objective:　To　investigate　the　influence　of　Fasudil,　a　Rho　inhibitor　on　the　number　and　functions　of　the　late　endothelial　progenitor　cells　in　peripheral　blood　of　chronic　obstructive　pulmonary　diseases　(COPD)　patients　with　pulmonary　artery　hypertension.　Background:　It　is　not　clear　yet,　whether　Rho　Kinase　Inhibitor　Fasudil　can　reduced　pulmonary　artery　pressure　through　improving　lung　endothelial　function.　Methods:　80　COPD　patients　with　pulmonary　artery　hypertension　were　selected　and　divided　into　two　groups:　the　treatment　group　and　the　control　group,　which　had　40　patients,　respectively.　Changes　in　the　number　and　function　of　the　late　endothelial　progenitor　cells　in　peripheral　blood　of　the　patients　before　and　after　the　treatment　were　compared　between　the　two　groups.　The　changes　on　the　pulmonary　artery　pressure　were　also　compared.　Results:　The　number　of　the　late　endothelial　progenitor　cells　in　peripheral　blood　of　the　treatment　group　increased　and　the　function　was　enhanced.　The　pulmonary　artery　pressure　was　reduced.　The　difference　before　and　after　the　treatment　and　with　the　control　group　was　statistically　significant　(p　＜　0.05).　Conclusions:　The　Rho-kinase　inhibitor　Fasudil　increased　the　number　and　enhanced　the　function　of　the　late　endothelial　progenitor　cells　in　peripheral　blood　of　COPD　patients　with　pulmonary　artery　hypertension　(Tab.　3,　Fig.　2,　Ref.　17).　Text　in　PDF　www.elis.sk.