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Author:

Zhu, Yanzhen (Zhu, Yanzhen.) | Zeng, Yanjun (Zeng, Yanjun.) | Wang, Xuan (Wang, Xuan.) | Ye, Xiaobao (Ye, Xiaobao.)

Indexed by:

Scopus SCIE

Abstract:

Clinically, electroacupuncture is proved to be an effective therapy for vascular dementia; however, their mechanisms remain uncertain. The aim of the current study was to investigate the mechanism of electroacupuncture therapy for vascular dementia. One month after a vascular dementia animal model was established by bilateral occlusion of common carotid arteries, electroacupuncture treatment was given at "Baihui" (DU20), "Dazhui" (DU14), and "Shenshu" (BL23). Morris water maze was used to assess the learning and memory ability of rats. Western blot assay was performed to detect the expression of mammalian target of rapamycin (mTOR) and eukaryotic translation initiation factor 4E (eIF4E) in hippocampus of rats. Morris water maze test showed that electroacupuncture improved the learning ability of vascular dementia rats. Western blot assay revealed that the expression level of mTOR and eIF4E in the electroacupuncture group and sham-operated group was higher than that in the vascular dementia group (P < 0.05). In conclusion, the decreasing expression of mTOR and eIF4E plays important roles in the pathogenesis of vascular dementia. Electroacupuncture improves learning and memory ability by up-regulating expression of mTOR and eIF4E in the hippocampus of vascular dementia rats.

Keyword:

Hippocampus mTOR eIF4E Electroacupuncture Vascular dementia

Author Community:

  • [ 1 ] [Zhu, Yanzhen]Fujian Univ Tradit Chinese Med, Dept Integrat Med, Fuzhou 350122, Fujian, Peoples R China
  • [ 2 ] [Ye, Xiaobao]Fujian Univ Tradit Chinese Med, Dept Integrat Med, Fuzhou 350122, Fujian, Peoples R China
  • [ 3 ] [Zeng, Yanjun]Beijing Univ Technol, Biomech & Med Informat Inst, Beijing 100022, Peoples R China
  • [ 4 ] [Wang, Xuan]Fujian Univ Tradit Chinese Med, Dept Acupuncture & Tuina, Fuzhou 350122, Fujian, Peoples R China

Reprint Author's Address:

  • [Zeng, Yanjun]Beijing Univ Technol, Biomech & Med Informat Inst, Beijing 100022, Peoples R China

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Source :

NEUROLOGICAL SCIENCES

ISSN: 1590-1874

Year: 2013

Issue: 7

Volume: 34

Page: 1093-1097

3 . 3 0 0

JCR@2022

ESI Discipline: NEUROSCIENCE & BEHAVIOR;

JCR Journal Grade:3

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 24

SCOPUS Cited Count: 24

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 6

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