Aim:　To　study　the　effects　of　an　extract　solution　from　radix　curcumae　on　the　expressions　of　VEGF,　COX-2　and　PCNA　in　gastric　mucosa　of　rats　during　carcinogenesis　induced　MNNG.　Methods:　Eighty　male　Wistar　rats　were　randomly　divided　into　5　groups:　group　A,　water　and　normal　saline;　group　B,　MNNG　and　normal　saline;　group　C,　MNNG　and　celecoxib;　group　D,　MNNG　and　low-dose　(1g/ml)　radix　curcumae　steam　distillation　extract　solution;　group　E,　MNNG　and　high-dose　(2g/ml)　radix　curcumae　wet　distillation　extract　solution.　In　the　end　of　the　40　th　week,　all　rats　alive　were　sacrificed　and　the　expressions　of　VEGF,　COX-2　and　PCNA　in　gastric　mucosa　were　determined　by　immunohistochemistry.　Results:　The　expression　levels　of　VEGF　and　COX-2　and　the　optical　density　levels　of　PCNA　in　group　C,　D　and　E　were　remarkably　lower　than　that　of　group　B　(P＜0.05),　while　the　optical　density　levels　of　PCNA　in　group　E　were　higher　than　that　of　group　C　and　D　(P＜0.05).　Conclusions:　The　distilled　extract　of　curcumae　can　down-regulate　the　expressions　of　VEGF,　COX-2　and　PCNA　in　the　gastric　mucosa　of　rats　during　carcinogenesis　induced　MNNG　and　can　reduce　the　incidence　of　gastric　caner,　suggesting　it　maybe　as　a　potential　chemopreventive　agent　for　gastric　cancer.