Bridge　structural　health　monitoring　system　is　very　necessary　to　master　operational　condition,　ensure　safety　of　structure,　detect　damage　and　conduct　effective　maintenance.　Based　on　the　health　monitoring　system　design　of　a　irregular　shaped　concrete-filled　steel　tube　arch　bridge,　this　paper　elaborates　on　the　design　principles　of　health　monitoring　system,　and　introduces　the　layout　proposal　of　all　kinds　of　sensors　on　the　bridge　and　the　matching　collection　system　and　software　system.　The　practice　may　provide　reference　for　the　health　monitoring　system　of　long-span　bridges.