Although　fruitful　research　results　have　been　achieved　on　the　investigation　of　size　effect　of　natural　coarse　aggregate　concrete　(NAC),　limited　research　is　devoted　to　the　study　on　size　effect　of　recycled　coarse　aggregate　concrete　(RAC).　Meanwhile,　the　feasibility　of　applying　these　results　on　NAC　to　RAC　is　questionable.　To　this　end,　a　synthesis　of　experimental　studies　with　different　recycled　coarse　aggregate　(RCA)　substitute　rates　(0%,　30%,　50%,　70%　and　100%),　different　prismatic　sizes　of　70　x　70　x　210,　100　x　100　x　300,　150　x　150　x　450　and　200　x　200　x　600　mm　are　carried　out　to　investigate　the　size　effect　of　RAC　with　consideration　of　the　influence　of　substitute　rate.　As　a　powerful　complement　to　the　experimental　study,　the　meso-scale　numerical　simulation　is　carried　out.　These　results　show　that　increasing　the　specimen　size　and　RCA　substitute　rate　both　leads　to　decreasing　nominal　compressive　strength　of　RAC.　Furthermore,　the　meso-scale　numerical　simulation　results　show　that　the　oblique　concentrated　damage　zone　is　more　likely　to　form　in　the　specimens　with　higher　RCA　substitute　rates,　which　exhibits　more　significant　size　effect.　In　addition,　the　size　effect　law　of　RAC　is　established　based　on　the　empirical　formula　and　back-propagation　neural　network,　respectively,　both　providing　an　accurate　prediction　of　nominal　compressive　strength　of　RAC　with　consideration　of　specimen　size　and　RCA　substitute　rate,　and　the　results　provide　some　references　for　the　design　specification　of　RAC　members.