ABS　T　R　A　C　T　In　this　paper,　a　CuCo-O@CNTs/NF　electrode　was　successfully　prepared　and　used　for　in-situ　degradation　of　sulfamethoxazole　(SMX)　in　an　electro-Fenton-like　system.　Carbon　nanotubes　(CNTs)　and　coral-like　copper-cobalt　oxides　were　successively　loaded　on　nickel　foam　(NF).　CNTs　contributed　to　improving　the　dispersibility　and　stability　of　copper-cobalt　oxides,　and　the　coral-like　copper-cobalt　oxide　catalyst　was　anchored　on　CNTs　without　any　adhesive.　In　the　electro-Fenton-like　system,　dissolved　oxygen　can　be　reduced　to　superoxide　anions　in　a　one-electron　step,　which　could　be　further　transformed　into　hydrogen　peroxide　and　then　reacted　with　the　active　components　on　the　electrode　to　generate　reactive　oxygen　species　(ROS)　to　participate　in　the　degradation　of　SMX.　Almost　100%　SMX　removal　was　obtained　within　60　min　in　a　wide　near-neutral　pH　range　(5.6-9.0),　and　the　electrode　could　still　achieve　a　90.4%　removal　rate　after　ten　recycle　runs.　Radical-quenching　results　showed　that　superoxide　anions　were　the　main　species　in　the　degradation　of　SMX.　In　addition,　a　possible　degradation　pathway　of　SMX　was　proposed.　According　to　the　result　of　toxicological　simulations,　the　toxicity　of　the　pollutant　solution　during　the　degradation　process　exhibited　a　decreasing　trend.　This　study　provides　new　insights　for　in-situ　catalysis　of　electrodes　with　bimetallic　active　components　to　generate　ROS　for　high-efficiency　degradation　of　refractory　organic　pollutants.