Environmental　contamination　with　antibiotics　has　become　a　global　crisis.　Heterogeneous　electro-Fenton　(EF)　technology　is　a　highly　efficient　approach　to　remove　antibiotics　from　wastewater.　In　this　study,　CuCe-layered　double　hydroxide　(LDH)　particles　were　fixed　on　the　carboxylated　carbon　nanotubes　(CNTs-COOH)　and　then　doped　on　foamed　copper　electrodes　(CuCe-LDHs/CNTs-COOH/CF).　The　CuCe-LDHs/CNTs-COOH/CF　electrode　was　used　as　the　cathode　for　sulfamethoxazole　(SMX)　degradation　in　the　heterogeneous　EF　procedure.　The　coexistence　of　CeIII/CeIV　and　CuI/CuII　redox　couples　led　to　significant　enhancement　in　the　interfacial　electron　transfer,　accelerated　the　in　situ　formation　and　decomposition　of　H2O2,　and　promoted　the　formation　of　O-center　dot(2)-　and　(OH)-O-center　dot　active　free　radicals.　The　electrode　demonstrated　good　stability,　low　metal-ion　leaching,　and　a　wide　pH　application　range.　The　results　show　that　within　90　min　almost　100.0%　of　SMX　([SMX]　=　10　mg　L-1)　was　degraded.　After　ten　cycles,　the　electrode　retained　high　stability　and　outstanding　catalytic　capacity.　Finally,　the　probable　paths　of　SMX　degradation　in　the　heterogeneous　EF　procedure　were　proposed,　and　the　biotoxicity　of　SMX　and　its　decomposition　products　during　degradation　was　systematically　evaluated.　This　study　can　supply　meaningful　ideas　for　designing　and　synthesizing　efficient　and　stable　cathodes　for　removing　antibiotics　from　wastewater　via　using　the　in　the　heterogeneous　EF　reaction　system.