The　heterogeneous　electro-Fenton　(hetero-EF)　technology　is　an　attractive　but　challenging　method　used　to　degrade　organic　pollutants.　The　development　of　a　catalysts　for　the　stable　and　efficient　degradation　of　pollutants　under　neutral　conditions　remains　a　challenging　task.　In　this　study,　a　microsphere　catalyst　consisting　of　magnetic　Cu-Fe-FeC3　on　nitrogen-doped　biochar　(Cu-Fe-Fe3C@NDB)　was　prepared　using　chitosan　as　the　carrier　material　in　a　two-step　process.　A　hetero-EF　system　using　Cu-Fe-Fe3C@NDB　as　the　catalyst　was　constructed　to　efficiently　degrade　amoxicillin.　The　catalyst　exhibited　a　wide　pH　application　range,　a　good　stability,　and　a　low　metal　ion　leaching.　The　main　reasons　behind　the　remarkable　catalytic　performance　and　excellent　stability　of　the　Cu-Fe-Fe3C@NDB　catalyst　are:　(i)　The　presence　of　a　core-shell　structure,　in　which　Cu-Fe　bimetallic　particles　are　wrapped　in　the　structure　of　biomass　carbon　to　slow　down　the　loss　of　the　metal　active　component　in　the　catalyst　and　maintain　its　stability;　(ii)　The　uniform　dispersion　of　nanoparticles　on　the　surface　of　the　Cu-Fe-Fe3C@NDB　catalyst,　N-doped　carbon,　and　the　combined　effect　of　Cu　and　Fe,　which　are　beneficial　to　improve　the　charge　transfer　efficiency　and　regulate　the　electronic　structure,　which　in　turns　improve　the　activity　of　the　catalyst.　This　work　demonstrates　that　the　efficient　degradation　of　pollutants　under　neutral　conditions　can　be　achieved　and　provides　useful　information　for　the　design　and　synthesis　of　efficient　and　stable　catalysts　in　hetero-EF　reaction　systems.