China　is　promoting　the　coordinated　development　of　the　Beijing-Tianjin-Hebei　region　as　a　national　strategy　project;　however,　water　scarcity　and　water　quality　problems　will　become　a　bottleneck　restricting　high-quality　development.　This　study　aimed　to　explore　a　feasible　industrial　synergy　optimisation　pathway　to　realise　the　collaborative　development　of　economic　growth　and　water　environment　improvement,　combined　with　incentives　for　environmental　efficiency　improvement　and　reclaimed　water　utilisation.　Research　methods　integrate　inputoutput　modelling,　system　dynamics,　and　multi-objective　programming　to　construct　a　complex　multi-region　model.　A　dynamic　simulation　measure　was　adopted　to　simulate　the　economic　and　environmental　impacts　of　different　approaches　that　mix　from　2020　to　2030　under　water　resource　environment　constraints.　According　to　the　simulation　results,　the　annual　economic　growth　rate　of　the　entire　region　can　exceed　6.1%,　and　the　emission　intensities　of　water　pollutants　decrease　by　more　than　60.0%.　In　addition,　traditional　manufacturing　industries　that　achieve　cross-regional　synergy　can　still　release　location　advantages　without　negative　environmental　impacts.　Furthermore,　regional　collaborative　development　optimises　the　allocation　of　water　resources　and　alleviates　water　stress.　Moreover,　the　pollutant　emission　reduction　effect　of　source　control　in　Hebei　was　more　effective　than　in　other　cities.　Finally,　reclaimed　water,　as　the　end　treatment　measure,　has　the　largest　marginal　effect　on　improving　the　trade-off　between　economic　and　environmental　improvement　in　the　long　run.　This　study　provides　a　new　approach　for　multi-regional　industrial　synergy　development　and　optimal　allocation　of　resources　and　contributes　to　the　high-quality　development　of　the　watershed.