Large-scale　injections　of　COVID-19　vaccine　and　formation　of　herd　immunity　are　currently　the　most　effective　way　to　combat　COVID-19　epidemic　in　the　world.　During　the　vaccination　process,　unexpected　security　incidents　are　likely　to　occur,　and　the　government　and　relevant　emergency　departments　have　the　responsibility　to　deal　with　these　emergent　security　incidents.　This　paper　proposes　an　AHP-TOPSIS　method,　establishes　the　evaluation　index　system,　determines　the　index　weight　combined　with　AHP,　and　uses　TOPSIS　to　rank　the　evaluation　objects,　so　as　to　evaluate　the　emergency　management　ability　of　the　government　and　relevant　departments　on　the　emergency　safety　events　of　COVID-19　vaccine.　This　is　of　great　positive　significance　for　continuously　strengthening　the　emergency　management　capacity　of　the　government　and　relevant　departments　and　ensuring　people＇s　life,　health　and　safety.　©　2022　SPIE