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Author:

Jin, Chunbo (Jin, Chunbo.) | Mao, Boyan (Mao, Boyan.) | Li, Bao (Li, Bao.) | Feng, Yue (Feng, Yue.) | Wu, Dandan (Wu, Dandan.) | Xie, Jinsheng (Xie, Jinsheng.) | Liu, Youjun (Liu, Youjun.) (Scholars:刘有军)

Indexed by:

EI Scopus SCIE

Abstract:

Background: When the coronary artery expands more than two times its diameter, it will form a coronary artery aneurysm (CAA). CAA can lead to myocardial ischemia. In this paper, the mechanism of myocardial ischemia induced by CAA was studied by geometric multiscale method. Methods: Four kinds of three-dimensional models of CAA with different dilation diameters were established on the basis of normal three-dimensional models. The dilation diameters were 2, 3, 5 and 7 times, capacitance was added after the CAA to simulate the elasticity of the vascular wall. Results: A large number of eddies exist in CAA. 2-7 times model: 1.1-14.4% reduction of blood flow downstream of CAA and 5, 7 times model showed upstream diastolic backward flow, the backward flow rate was 1.1% and 5.6%, respectively. The aveWSS at the CAA was 1.76-0.35Pa; the relative retention time was 1.1-14.6 Pa-1; the average vorticity was 0.0085-231.7s(-1). Conclusion: CAA can store blood, and the elasticity of the wall of CAA results in the flow of blood upstream. These two reasons make the downstream flow of CAA decrease and easily form intratumoral thrombosis, which may lead to myocardial ischemia.

Keyword:

geometric multi-scale model myocardial ischemia hemodynamics Coronary artery aneurysm (CAA)

Author Community:

  • [ 1 ] [Jin, Chunbo]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing, Peoples R China
  • [ 2 ] [Mao, Boyan]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing, Peoples R China
  • [ 3 ] [Li, Bao]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing, Peoples R China
  • [ 4 ] [Feng, Yue]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing, Peoples R China
  • [ 5 ] [Wu, Dandan]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing, Peoples R China
  • [ 6 ] [Liu, Youjun]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing, Peoples R China
  • [ 7 ] [Xie, Jinsheng]Capital Med Univ, Beijing Anzhen Hosp, 2 Anzhen Rd, Beijing, Peoples R China

Reprint Author's Address:

  • 刘有军

    [Liu, Youjun]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing, Peoples R China

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Source :

JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY

ISSN: 0219-5194

Year: 2020

Issue: 3

Volume: 20

0 . 8 0 0

JCR@2022

ESI Discipline: MOLECULAR BIOLOGY & GENETICS;

ESI HC Threshold:219

Cited Count:

WoS CC Cited Count: 2

SCOPUS Cited Count: 2

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 5

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