N6-methyladenosine　(m6A)　is　the　most　abundant　post-transcription　modification,　widely　occurring　in　eukaryotic　mRNA　and　non-coding　RNA.　m6A　modification　is　highly　enriched　in　the　mammalian　brain　and　is　associated　with　neurological　diseases　like　Alzheimer’s　disease　(AD)　and　Parkinson’s　disease　(PD).　Ischemic　stroke　(IS)　was　discovered　to　alter　the　cerebral　m6A　epi-transcriptome,　which　might　have　functional　implications　in　post-stroke　pathophysiology.　Moreover,　it　is　observed　that　m6A　modification　could　regulate　microglia’s　pro-inflammatory　and　anti-inflammatory　responses.　Given　the　critical　regulatory　role　of　microglia　in　the　inflammatory　processes　in　the　central　nervous　system　(CNS),　we　speculate　that　m6A　modification　could　modulate　the　post-stroke　microglial　inflammatory　responses.　This　review　summarizes　the　vital　regulatory　roles　of　m6A　modification　in　microglia-mediated　inflammation　and　IS.　Stroke　is　associated　with　a　high　recurrence　rate,　understanding　the　relationship　between　m6A　modification　and　stroke　may　help　stroke　rehabilitation　and　develop　novel　therapies　in　the　future.　Copyright　©　2022　Zhang,　Ran,　Tahir,　Li,　Wang　and　Chen.