Renal　sympathetic　denervation　(RDN)　is　an　effective　approach　for　uncontrolled　hypertension.　Although　several　studies　have　compared　the　ablation　characteristics　at　various　locations,　there　is　no　direct　comparative　study　on　the　effect　of　ablation　in　main　and　branch　renal　artery　(RAs)　and　different　electrode　materials.　The　study　aims　to　investigate　the　effect　of　different　electrode　materials　(copper,　gold,　and　platinum)　and　positions　(proximal,　middle,　or　distal　site)　on　ablation.　A　3D　patient-specific　renal　artery　model　and　a　unipolar　model　(470　kHz)　were　constructed　to　mimic　RDN.　Two　therapeutic　strategies,　including　main　(site　1　and　2)　and　branch　(site　3)　ablations　were　simulated　with　three　electrode　materials.　The　finite　element　method　was　used　to　calculate　the　coupled　electric-thermal-flow　field.　Maximum　lesion　depth,　width,　area,　and　lesion　angle　were　analyzed.　The　results　showed　that　the　difference　in　lesion　width　and　depth　was　no　mere　than　0.5　mm,　and　the　maximum　difference　value　in　lesion　area　is　0.683　mm(2)　among　three　electrode　materials.　The　lesion　angle　of　proximal　site　1　versus　middle　site　2　was　58.39　degrees　and　52.23　degrees,　but　the　difference　between　distal　site　3　and　site　1,　or　site　2　was　29.19　degrees　and　35.35　degrees　respectively.　There　is　no　significant　difference　in　the　use　of　the　three　electrode　materials,　and　ablation　at　the　distal　site　of　the　artery　is　more　effective.