This　paper　proposes　a　comprehensive　mesoscale　modelling　approach　with　thermo-mechanical　coupling,　ac-counting　for　the　meso-structure　characteristics　and　ice-strengthening　effect　to　capture　the　compressive　me-chanical　performances　of　concrete　at　various　low　temperatures.　Meso-structure　of　cryogenic　concrete　composed　coarse　aggregates,　mortar　matrix　and　the　equivalent　ice　was　modelled　and　a　2-stage　numerical　analysis　was　conducted.　The　first　stage　was　heat　conduction　analysis　of　cryogenic　concrete　which　aimed　to　obtain　the　tem-perature　and　stress　field　distributions.　Based　on　the　heat　conduction,　uniaxial　compressive　failure　analysis　was　subsequently　conducted,　which　discussed　the　influences　of　environmental　temperature,　moisture　content　and　specimen　size.　Results　show　that　the　ice　can　directly　resist　partial　external　load　at　the　initial　stage　of　compressive　loading　and　the　expansion　of　ice　produces　prestress　on　the　surrounding　mortar　matrix　which　will　suffer　a　multiaxial　stress　state.　Consequently,　the　compressive　strength,　elastic-modulus　as　well　as　energy　absorption　of　concrete　are　enhanced　with　the　dropping　temperature,　showing　a　low　temperature　strengthening　effect　which　is　enhanced　as　the　moisture　content　increases　or　the　specimen　size　decreases.　A　good　consistency　between　the　simulations　and　tests　indicates　that　the　established　mesoscale　modelling　approach　can　effectively　reproduce　the　compressive　fracture　failure　behaviour　of　cryogenic　concrete,　which　contributes　to　developing　the　soundness　assessment　for　cryogenic　concrete　materials.