Highly　3D　ordered　honeycomb-shaped　xCuO　center　dot　Mn2O3　(CuO　content　(x)　=　10,　20,　and　30　wt%)　catalysts　with　various　CuO　contents　were　synthesized　by　adopting　a　colloidal　crystal　template　method　with　poly(methyl　methacrylate)　(PMMA)　as　template,　and　the　as-prepared　catalysts　were　used　in　oxidation　of　CO.　The　catalysts　possessed　a　macro-mesoporous　structure.　The　catalytic　performance　at　low　temperatures　improved　significantly　with　a　rise　in　CuO　content.　The　light-off　temperature　(10　%　conversion)　and　the　temperature　for　CO　complete　conversion　were　71　and　98　degrees　C　over　30　wt%　CuO　center　dot　Mn2O3,　respectively.　Good　stability　of　the　30　wt%　CuO　center　dot　Mn2O3　catalyst　was　also　observed　under　the　dry　and　wet　(in　the　presence　of　water　vapor)　conditions.　It　is　concluded　that　high　catalytic　activity　of　30　wt.%　CuO　center　dot　Mn2O3　was　related　to　its　unique　pore　structure,　high　oxygen　adspecies　concentration,　and　oxygen　vacancy.