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Author:

Huang, Yong (Huang, Yong.) | Zeng, Yan (Zeng, Yan.) | Bin, Guangyu (Bin, Guangyu.) | Ding, Qiying (Ding, Qiying.) | Wu, Shuicai (Wu, Shuicai.) | Tai, Dar-In (Tai, Dar-In.) | Tsui, Po-Hsiang (Tsui, Po-Hsiang.) | Zhou, Zhuhuang (Zhou, Zhuhuang.)

Indexed by:

Scopus SCIE

Abstract:

The early detection of hepatic fibrosis is of critical importance. Ultrasound backscattered radiofrequency signals from the liver contain abundant information about its microstructure. We proposed a method for characterizing human hepatic fibrosis using one-dimensional convolutional neural networks (CNNs) based on ultrasound backscattered signals. The proposed CNN model was composed of four one-dimensional convolutional layers, four one-dimensional max-pooling layers, and four fully connected layers. Ultrasound radiofrequency signals collected from 230 participants (F0: 23; F1: 46; F2: 51; F3: 49; F4: 61) with a 3-MHz transducer were analyzed. Liver regions of interest (ROIs) that contained most of the liver ultrasound backscattered signals were manually delineated using B-mode images reconstructed from the backscattered signals. ROI signals were normalized and augmented by using a sliding window technique. After data augmentation, the radiofrequency signal segments were divided into training sets, validation sets and test sets at a ratio of 80%:10%:10%. In the test sets, the proposed algorithm produced an area under the receive operating characteristic curve of 0.933 (accuracy: 91.30%; sensitivity: 92.00%; specificity: 90.48%), 0.997 (accuracy: 94.29%; sensitivity: 94.74%; specificity: 93.75%), 0.818 (accuracy: 75.00%; sensitivity: 69.23%; specificity: 81.82%), and 0.934 (accuracy: 91.67%; sensitivity: 88.89%; specificity: 94.44%) for diagnosis liver fibrosis stage >= F1, >= F2, >= F3, and >= F4, respectively. Experimental results indicated that the proposed deep learning algorithm based on ultrasound backscattered signals yields a satisfying performance when diagnosing hepatic fibrosis stages. The proposed method may be used as a new quantitative ultrasound approach to characterizing hepatic fibrosis.

Keyword:

convolutional neural network ultrasound tissue characterization hepatic fibrosis ultrasound backscattered signal deep learning

Author Community:

  • [ 1 ] [Huang, Yong]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 2 ] [Zeng, Yan]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 3 ] [Bin, Guangyu]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 4 ] [Wu, Shuicai]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 5 ] [Zhou, Zhuhuang]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 6 ] [Ding, Qiying]Beijing Univ Technol, BJUT Hosp, Dept Ultrasound, Beijing 100124, Peoples R China
  • [ 7 ] [Tai, Dar-In]Chang Gung Univ, Chang Gung Mem Hosp Linkou, Dept Gastroenterol & Hepatol, Taoyuan, Taiwan
  • [ 8 ] [Tsui, Po-Hsiang]Chang Gung Univ, Coll Med, Dept Med Imaging & Radiol Sci, Taoyuan, Taiwan
  • [ 9 ] [Tsui, Po-Hsiang]Chang Gung Univ, Inst Radiol Res, Taoyuan, Taiwan
  • [ 10 ] [Tsui, Po-Hsiang]Chang Gung Mem Hosp Linkou, Dept Pediat, Div Pediat Gastroenterol, Taoyuan, Taiwan

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Source :

DIAGNOSTICS

Year: 2022

Issue: 11

Volume: 12

3 . 6

JCR@2022

3 . 6 0 0

JCR@2022

ESI Discipline: CLINICAL MEDICINE;

ESI HC Threshold:38

JCR Journal Grade:2

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count: 5

SCOPUS Cited Count: 5

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 9

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