The　widespread　detection　and　potential　adverse　effects　of　antibiotics　in　the　aquatic　environment　call　for　effective　treatment　technology.　Electro-Fenton　is　a　promising　strategy,　but　the　preparation　of　efficient　and　stable　cathodes　is　still　challenging.　In　this　study,　a　novel　metal-organic　framework　(MOF)-derived　N-doped　cathode　Fe/Cu-C40　0Ar　was　synthesized　successfully　for　the　degradation　of　ceftazidime　(CAZ)　in　hetero-geneous　electro-Fenton　(hetero-EF)　system.　The　doping　of　copper　could　enhance　electrocatalysis　with　a　high　electrochemical　surface　active　area　and　low　resistance.　Fe/Cu-C40　0Ar　cathode　achieved　CAZ　removal　efficiency　of　99.5　+/-　0.4%　within　120　min,　and　it　exhibited　excellent　stability　after　six　recycle　runs.　Quenching　experiments　and　electron　paramagnetic　resonance　(EPR)　tests　proved　that　the　primary　species　was　hydroxyl　radical　during　the　CAZ　degradation.　In　addition,　the　degradation　pathway　of　CAZ　was　pro-posed　including　the　cleavage　of　the　pyridine　ring　and　the　shedding　of　the　thiazole　ring.　Moreover,　the　prediction　of　intermediates　toxicity　by　Ecological　Structure　Activity　Relationships　(ECOSAR)　software　in-dicated　the　environmentally　friendly　features　of　the　CAZ　degradation　process.　This　study　provided　a　pro-mising　cathode　for　the　electrocatalytic　degradation　of　antibiotic　wastewater　in　hetero-EF　system.(c)　2023　Elsevier　B.V.　All　rights　reserved.