Hydrogen　production　from　electrolytic　water　is　an　important　sustainable　technology　to　realize　renewable　energy　conversion　and　carbon　neutrality.　However,　it　is　limited　by　the　high　overpotential　of　oxygen　evolution　reaction　(OER)　at　the　anode.　To　reduce　the　operating　voltage　of　electrolyzer,　herein　thermodynamically　favorable　glycerol　oxidation　reaction　(GOR)　is　proposed　to　replace　the　OER.　Moreover,　vertical　NiO　flakes　and　NiMoNH　nanopillars　are　developed　to　boost　the　reaction　kinetics　of　anodic　GOR　and　cathodic　hydrogen　evolution,　respectively.　Meanwhile,　excluding　the　explosion　risk　of　mixed　H-2/O-2,　a　cheap　organic　membrane　is　used　to　replace　the　expensive　anion　exchange　membrane　in　the　electrolyzer.　Impressively,　the　electrolyzer　delivers　a　remarkable　reduction　of　operation　voltage　by　280　mV,　and　exhibits　good　long-term　stability.　This　work　provides　a　new　paradigm　of　hydrogen　production　with　low　cost　and　good　feasibility.