A　prefabricated　lightweight　steel　composite　frames–perlite　insulation　reinforced　with　steel　wire　mesh　composite　wall　(PSW)　structure　suitable　for　low-rise　buildings　in　villages　was　proposed.　The　lightweight　steel　composite　frame　was　composed　of　square　CFST　columns,　H-shaped　steel　beams,　double　L-shaped　joints,　and　concrete　floors.　The　perlite　insulation　reinforced　with　steel　wire　mesh　composite　wall　was　composed　of　steel　wire　mesh　reinforced　mortar　surface,　perlite　board,　and　EPS　board.　The　lightweight　steel　composite　frame　was　enclosed　by　PSW.　The　lightweight　steel　composite　frame　and　PSW　were　assembled　through　the　new　connection　of　“packaging　and　gripping”.　The　wall　units　were　connected　through　the　“tongue-and-groove”　connection.　A　full-scale　two-story　prefabricated　lightweight　steel　composite　frames-perlite　insulation　reinforced　with　steel　wire　mesh　composite　wall　structure　was　subjected　to　seismic　loading　under　57　working　conditions　including　white　noise　(PGA:　0.07g~1.50g).　The　damage　evolution　process,　stiffness　degradation,　displacement　response,　and　strain　characteristics　were　discussed　and　analyzed.　The　results　showed　that:　The　PSW　worked　together　with　a　lightweight　steel　composite　frame　and　the　PSW　improved　the　lateral　stiffness　of　the　lightweight　steel　composite　frame;　With　the　increase　of　the　input　peak　ground　acceleration　(PGA),　the　natural　frequency　of　the　structure　decreased　and　the　damping　ratio　increased;　Under　the　action　of　8-degree　fortification　earthquake　(0.20g),　the　maximum　story　displacement　angle　was　1/361,　and　the　structure　was　in　the　elastic　stage;　There　was　no　significant　damage　to　the　structure　under　the　action　of　8-degree　rare　earthquake　(0.51g);　Under　the　action　of　an　extremely　rare　earthquake,　the　damage　of　exterior　wall　was　obvious,　and　the　lightweight　steel　composite　frame　was　basically　intact.　The　flexible　connection　of　“packaging　and　gripping”　weakened　the　seismic　response　of　the　wall　and　improves　the　energy　dissipation　between　the　PSW　and　the　lightweight　steel　composite　frame.　©　2023　Editorial　Department　of　Journal　of　Sichuan　University.　All　rights　reserved.