Self-healing　behavior　of　binder　has　important　potential　for　promoting　low-carbon　service　and　extending　service　life　of　asphalt　pavement.　A　novel　self-healing　polyurethane　modified　asphalt　with　dynamic　covalent　bonds　was　prepared　in　this　work.　The　chemical　structure,　thermal-oxygen　stability,　rheological　properties,　fatigue　properties　and　self-healing　capability　of　polyurethane　modified　asphalt　with　dynamic　covalent　bonds　were　systemically　investigated　through　Fourier　infrared　spectrum　test,　thermal　gravimetric　test,　dynamic　shear　rheology　test,　linear　amplitude　sweep(LAS)　test　and　multiple　fatigue-healing-fatigue　test.　The　result　indicates　disulfide　dynamic　covalent　bond　and　oxime　urethane　dynamic　covalent　bond　were　successfully　introduced　into　polyurethane　cross-linking　structure　in　asphalt,　and　the　thermal-oxygen　stability　of　asphalt　has　a　significant　increase　after　modification　under　the　environmental　conditions　of　construction　and　service.　Rheological　properties　analysis　suggests　the　introduction　of　dynamic　covalent　bonds　is　beneficial　to　improve　the　low-temperature　toughness　of　polyurethane　modified　asphalt,　and　enhances　its　low-temperature　cracking　resistance.　LAS　analysis　indicates　the　fatigue　life　of　polyurethane　modified　asphalt　can　also　be　lengthened　by　over　70%　at　different　strain　levels(1.5%,　2.5%　and　5%)　with　the　introduction　of　dynamic　covalent　bonds,　which　is　attributed　to　the　excellent　conformation　adjustment　ability　and　stress　dissipation　ability　of　dynamic　cross-linking　structure　in　asphalt.　The　multiple　fatigue-healing-fatigue　test　shows　the　self-healing　capability　of　polyurethane　modified　asphalt　has　an　improvement　with　the　introduction　of　dynamic　covalent　bonds,　especially　at　the　later　stage　with　serious　fatigue　damage,　and　oxime　urethane　dynamic　covalent　bond　shows　the　better　contribution　effect　as　compared　with　disulfide　bond.　This　is　due　to　the　reversible　fracture-rearrangement　characteristics　of　dynamic　covalent　bonds.　This　work　provides　a　new　idea　for　improving　the　self-healing　capacity　and　rheological　properties　of　binder,　reducing　the　frequency　of　pavement　maintenance　and　extending　the　pavement　service　life.　©　2023　Elsevier　Ltd