To　develop　an　effective　warning　strategy　for　driving　fatigue　on　grassland　highway,　which　is　based　on　the　prone　points　of　driver　fatigue　during　driving　on　grassland　highway,　drivers　were　divided　into　three　types　of　stimulation　preference　(i.　e.,　visual,　auditory,　and　tactile)　according　to　stress　response　theory　and　neuro-linguistic　program　theory.　The　existing　typical　anti-fatigue　on-board　equipment　was　referenced　to　determine　the　stimulation　means　and　parameters　for　driving　fatigue.　A　personalized　anti-fatigue　warning　strategy　was　constructed　to　satisfy　drivers＇　various　preferences　for　stimulus　selection.　The　effectiveness　of　this　strategy　was　verified　by　driving　simulator　experiments.　Results　show　that　compared　with　other　stimulus　modes　and　blank　control　group,　when　the　type　of　warning　stimulus　was　preferred　by　drivers,　the　self-rating　value　of　driving　fatigue　state,　speed　eigenvalue,　acceleration　eigenvalue,　lateral　offset　eigenvalue　and　throttle　power　eigenvalue　changed　the　least　before　and　after　the　experiment.　Drivers　have　the　highest　understanding　and　acceptance　as　well　as　the　least　disturbance　of　the　preferred　warning　stimulus.　The　evaluation　results　by　TOPSIS　method　indicated　that　different　stimulus　modes　had　different　effects　on　alleviating　driving　fatigue.　With　the　deepening　of　fatigue　degree,　drivers＇　preferred　warning　stimulus　would　alleviate　driving　fatigue　more　effectively.　©　2023　Beijing　University　of　Technology.　All　rights　reserved.