To　alleviate　driving　fatigue　caused　by　driving　on　grassland　roads,　an　anti-fatigue　warning　strategy　based　on　information　demand　of　individual　drivers　was　designed.　Based　on　the　questionnaire,　drivers　were　divided　into　three　categories:　visual　type,　auditory　type　and　tactile　type.　Considering　different　types　of　drivers′　customized　warning　information　demand,　three　kinds　of　driving　fatigue　warning　strategies　on　grassland　roads　were　designed,　including　road　warning,　vehicle　warning　and　vehicle-road　cooperation　warning.　21　drivers　were　selected　to　carry　out　driving　simulator　experiment.　The　data　of　KSS　scale,　subjective　evaluation　of　warning　strategy　and　driving　behavior　were　obtained.　The　methods　of　descriptive　analysis,　statistical　analysis　and　TOPSIS　comprehensive　evaluation　based　on　entropy　weight　were　applied　to　test　the　effectiveness　of　three　driving　fatigue　warning　strategies.　The　results　shown　that　drivers′　acceptance　of　the　three　warning　strategies　was　high;　these　three　warning　strategies　could　alleviate　the　driving　fatigue　status　in　different　degrees,　the　cooperative　warning　strategy　was　superior　to　the　other　two　strategies.　Moreover,　the　alleviation　effect　of　the　cooperative　warning　strategy　was　more　obvious　when　the　driving　fatigue　degree　was　deeper.　The　cooperative　driving　fatigue　warning　strategy　based　on　customized　information　demand　of　individual　drivers　was　helpful　to　improve　the　prevention　effect　of　driving　fatigue　on　grassland　roads.　©　2024　Harbin　Institute　of　Technology.　All　rights　reserved.