Enantiomeric　excess　(ee)　is　an　essential　indicator　of　chiral　drug　purification　in　the　pharmaceutical　industry.　However,　to　date　the　ee　determination　of　unknown　concentration　enantiomers　generally　involves　two　separate　techniques　for　chirality　and　concentration　measurement.　Here,　a　whispering-gallery　mode　(WGM)　based　optofluidic　microlaser　near　exceptional　point　to　achieve　the　ee　determination　under　unknown　concentration　with　a　single　technique　is　proposed.　Exceptional　point　induces　the　unidirectional　WGM　lasing,　providing　the　optofluidic　microlaser　with　the　novel　capability　to　measure　chirality　by　polarization,　in　addition　to　wavelength-based　concentration　detection.　The　dual-parameters　detection　of　optofluidic　microlaser　empowers　it　to　achieve　ee　determination　of　various　unknown　enantiomers　without　additional　concentration　measurements,　a　feat　that　is　challenging　to　accomplish　with　other　methods.　Featuring　the　sensitivity　enhancement　and　miniature　structure　of　the　WGM　sensors,　the　obtained　chiroptical　response　of　the　present　approach　is　approximate　to　30-fold　higher　than　that　of　the　conventional　optical　rotation-based　polarimeter,　and　the　reagent　consumption　is　reduced　by　three　orders　of　magnitude.　By　inducing　the　exceptional　point,　the　whispering-gallery　mode-based　optofluidic　microlaser　is　enhanced　with　the　novel　capability　to　measure　chirality　of　enantiomer　by　polarization,　in　addition　to　wavelength-based　concentration　detection.　The　dual-parameters　detection　of　optofluidic　microlaser　empowers　it　to　achieve　enantiomeric　excess　determination　of　various　unknown　enantiomers　by　a　single　technique,　a　feat　that　is　challenging　to　accomplish　with　other　methods.image