In　the　wake　of　epochal　international　developments,　such　as　Brexit,　the　Sino-American　trade　tensions,　and　global　health　crises　exemplified　by　the　outbreak　of　what　is　referred　to　as　Newcastle　pneumonia,　the　impetus　towards　regional　economic　integration　has　escalated　as　a　strategic　imperative　for　economies　seeking　resilience　against　multifaceted　economic　shocks.　Concomitantly,　there　is　a　discernible　shift　characterized　by　the　re-shoring　of　manufacturing,　offshoring　of　industrial　chains,　and　domestication　of　production　processes.　This　shifting　landscape　necessitates　rigorous　investigation　into　the　stability　of　regional　economic　systems.　Leveraging　an　innovative　framework　premised　on　ecological　nested　structure　theory,　this　study　undertakes　a　tripartite　empirical　examination　of　production　network　stability　within　the　Asia-Pacific　realm　through　measurement,　simulation,　and　evolutionary　analyses.　Our　findings　illuminate　that　the　morphology　of　global　and　regional　production　networks　conforms　to　a　“core-periphery”　topology.　The　evolutionary　dynamics　and　concomitant　economic　ramifications　of　this　structure　find　congruence　with　the　Local　World　Evolutionary　Network　model　within　network　science.　Furthermore,　we　posit　that　nested　metrics　offer　robust　quantification　of　the　stability　of　these　economic　systems.　Notably,　the　generalist　industrial　sectors　that　are　situated　within　the　nested　core　contribute　to　the　network’s　stability,　whereas　specialist　sectors　induce　potential　destabilization.　Simulation　analyses　using　nested　metrics　reveal　a　strong　correlation　between　a　nation　(region)’s　role　and　its　position　within　the　production　network,　and　the　nation　(region)’s　level　of　economic　development　and　capacity　for　risk　mitigation.　Moreover,　an　evolutionary　examination　of　the　Regional　Comprehensive　Economic　Partnership　(RCEP)　affirms　that　augmenting　trade　volumes　among　member　states　fortifies　the　stability　of　(cross-border)　production　networks　in　the　Asia-Pacific　region,　which,　in　turn,　fosters　economic　growth　and　industrial　optimization　within　the　constituent　countries　(regions).　©　2023　Systems　Engineering　Society　of　China.　All　rights　reserved.