Nested　structure　is　a　structural　feature　that　is　conducive　to　system　stability　formed　by　co-evolution.　In　our　opinion,　it　is　just　like　what　the　biological　species　do　in　the　mutualistic　ecosystem　that　enterprises　collaborate　to　apply　for　patents　in　the　technical　cooperation　network,　changing　to　form　one　dynamic　equilibrium　after　another.　In　this　paper,　a　nestedness-based　analytical　framework　is　built　to　reflect　the　topological　stability　of　the　technical　cooperation　network　of　Zhongguancun　Science　Park　(Z-Park).　We　study　why　this　technically　mutualistic　ecosystem　can　reach　a　stable　equilibrium　with　time　going　by,　as　well　as,　we　propose　an　index　called　Nestedness　Disturbance　Index　(NDI)　to　study　what　the　role　park　areas　and　technical　fields　play　in　the　steady　states.　©　2023,　The　Author(s),　under　exclusive　license　to　Springer　Nature　Switzerland　AG.