To　solve　the　problems　faced　by　the　flange　connection　in　the　application　of　concrete　piers,　such　as　difficult　connection　implementation,　indistinct　force　mechanism,　and　unclear　seismic　performance,　this　paper　proposes　a　new　flange　connection-based　centrifugal　circular　hollow　segmental　RC　column-column　node　assembly　scheme.　Thus,　the　prefabricated　assembly　technology　of　the　bridge　substructure　can　be　further　improved.　Based　on　the　Jianli-Jiangling　Expressway　Honghu　No.　1　Special　Bridge　project,　a　5.　6　m　height　1∶　1　full-scale　model　was　designed　and　fabricated.　Its　seismic　performance　and　failure　modes　were　studied　by　conducting　the　quasi-static　load　test　and　numerical　simulation　analysis.　Based　on　the　yield　line　theory　and　T-node　model,　the　force　mechanism　of　plates　and　bolts　in　flange　connection　nodes　was　analyzed,　and　the　calculation　model　of　the　bending　resistance　of　flange　connection　nodes　was　established.　Results　show　that　when　the　flange　node　is　set　at　the　most　unfavorable　bearing　position,　which　is　the　plastic　hinge　area　at　the　bottom　of　the　pier,　the　mechanical　properties　of　flange-connected　precast　piers　are　close　to　those　of　conventional　cast-in-place　piers　in　the　elastic　phase　and　meet　the　seismic　design　requirements　of　low-intensity　zones　in　the　actual　projects.　However,　the　damage　occurs　at　the　flange　node　after　the　bridge　pier　yielded,　which　indicates　that　its　energy　dissipation　capacity　has　some　limitations.　Therefore,　further　research　is　needed　for　the　application　in　medium　and　high-intensity　zones.　The　proposed　node　force　model　reasonably　explains　the　cause　of　the　damage.　Accordingly,　a　design　method　for　plate　thickness　and　reinforcement　diameter　applicable　to　this　flange　connection　node　is　proposed　to　provide　design　recommendations　for　future　applications　in　medium　and　high-intensity　zones.　©　2023　Beijing　University　of　Technology.　All　rights　reserved.