Background:　Natural　products　are　valuable　resources　for　drugs　research　and　development.　The　separation　and　purification　of　particular　drug　molecule　from　multiple　structural　analogs　remains　a　great　challenge.　Borneol　is　a　natural　product　widely　used　for　the　treatment　of　the　cardiovascular　and　cerebrovascular　diseases.　It　is　very　challenging　to　be　purified　due　to　the　presence　of　camphor　with　similar　molecular　structure,　which　limits　the　supply　of　high-purity　borneol.　Methods:　Seven　kinds　of　metal-organic　frameworks　(MOFs)　are　used　for　the　first　time　to　explore　the　borneol/camphor　mixture　separation.　The　adsorption　kinetics　and　isotherms　of　borneol　and　camphor　for　MIL-101(Cr)　were　evaluated.　Significant　findings:　Among　these　MOFs,　MIL-101(Cr)　exhibited　the　best　performance　with　the　borneol/camphor　selectivity　of　4.3　and　the　borneol　adsorption　capacity　of　495　mg·g　−　1　at　298　K.　The　fast　adsorption　kinetics　with　the　equilibrium　time　of　30　min　at　298　K　enabled　high　separation　efficiency　under　dynamic　conditions.　The　high-purity　borneol　(＞　98　%)　can　be　obtained　through　the　three-stage　purification　processes.　Furthermore,　the　material　is　stable　and　reusable　for　multiple　cycles　without　obvious　decrease　of　the　performance,　indicating　high　potential　for　practical　application.　©　2024　Taiwan　Institute　of　Chemical　Engineers