Improving　the　uniformity　of　bus　arrival　intervals　and　operational　service　reliability　through　effective　control　strategies　is　an　important　way　to　enhance　the　quality　of　bus　services　and　the　satisfaction　of　passengers.　First,　a　bus　operation　model　was　developed　in　consideration　of　the　fluctuation　of　passenger　boarding　demand　at　stops.　Second,　a　bus　interval　speed　regulation　strategy　was　proposed　based　on　travel　time　deviation　feedback　mechanism,　and　then　a　station　passenger　information　guidance　strategy　was　designed　based　on　the　boarding　choice　behavior　model.　To　minimize　passenger　travel　costs　and　bus　headway　deviations,　this　paper　proposed　a　combination　optimization　control　strategy　integrating　speed　regulation　and　boarding　guidance　for　bus　operation　and　the　solution　method.　Taking　the　bus　Route　No.　57　in　Beijing　as　an　example,　this　paper　performed　the　numerical　simulation　comparison　experiments　for　four　scenarios.　The　results　show　that　the　combination　control　strategy　has　the　best　optimization　effect.　Compared　with　the　no　control　strategy,　the　stability　of　bus　operation　has　been　improved　by　47.7%　through　the　proposed　method,　and　the　bus　bunching　on　the　route　was　avoided.　The　comprehensive　cost　considering　travel　time　and　congestion　has　been　reduced　by　18.71%.　The　study　also　compared　the　optimization　effects　of　strategies　under　different　passenger　income　levels　and　passenger　guidance　information　compliance　rates.　The　results　show　that　the　effect　of　information　guidance　strategies　on　reducing　total　travel　costs　reduce　as　income　levels　increase.　When　the　passenger　guidance　information　compliance　rate　is　0.7.　The　combination　control　strategy　has　the　most　significant　improvement　effect　on　bus　operation　and　passenger　travel.　This　study　can　provide　important　support　for　the　bus　operation　reliability　and　service　quality　improvement.　©　2023　Science　Press.　All　rights　reserved.