Neural　signals　play　a　crucial　role　in　unraveling　the　mysteries　of　the　nervous　system.　However,　due　to　their　minute　amplitudes　in　the　range　of　microamperes　and　microvolts,　recording　these　signals　poses　significant　challenges,　largely　stemming　from　their　vulnerability　to　noise　interference.　Thus,　the　development　of　neural　signal　acquisition　circuits　holds　paramount　importance.　This　paper　presents　a　successful　endeavor　in　designing　an　integrated　circuit　using　0.18um　CMOS　technology,　which　exhibits　exceptional　accuracy　in　recording　neural　signals.　The　circuit　employs　a　combination　of　amplifiers　and　filters,　while　incorporating　the　innovative　blanking　technology　to　effectively　eliminate　unwanted　noise.　Remarkably,　this　design　accomplishes　an　impressive　gain　of　88.437dB.　Consequently,　the　circuit　enables　the　accurate　capture　of　nerve　signals,　thereby　positioning　itself　as　an　ideal　candidate　for　implantable　neural　signal　detection　devices.　With　its　ability　to　overcome　the　hurdles　associated　with　signal　sensitivity　and　noise　interference,　this　integrated　circuit　represents　a　significant　advancement　in　the　field　of　neural　signal　acquisition,　holding　immense　potential　for　further　exploration　and　application　in　neuroscientific　research　and　medical　interventions.　©　2023　Institute　of　Physics　Publishing.　All　rights　reserved.