Zwitterionic　nanofiltration　membranes,　with　high　rejection　to　organic　molecules　while　low　rejection　to　monovalent　salts,　are　promising　for　antibiotic　desalination.　However,　due　to　the　heterogeneous　issue　of　interfacial　polymerization,　the　residual　amine　groups　result　in　polymer　chain　aggregation　via　hydrogen　bonds,　blocking　the　mass　transfer　of　water　and　monovalent　salts.　Herein,　EtOH-assisted　Michael-addition/Schiff-base　reaction　strategy　was　proposed　to　solve　the　issue.　NaOH　was　initially　utilized　to　provisionally　interrupt　the　hydrogen　bonds　between　polymer　chains.　Meanwhile,　with　the　assistance　of　EtOH,　gallic　acid　diffused　into　the　membrane　and　reacted　with　the　amine　groups　on　the　polymer　chains　to　form　covalent　bonds,　which　thoroughly　destroyed　the　stacking　of　polymer　chains.　As　a　consequence,　water　permeance　and　antibiotic　desalination　efficiency　of　the　membrane　are　improved.　For　example,　the　pure　water　permeance　reaches　8.9　L　m−2　h−1　bar−1,　1.7-fold　enhancement　compared　with　the　pristine　membrane.　The　membrane　is　applied　for　antibiotic　desalination,　offering　long-term　running　stability,　antifouling　ability,　as　well　as　high　efficiency　in　concentrated　antibiotics.　©　2024