Ferroptosis　is　a　form　of　regulated　cell　death　(RCD)　characterized　by　iron-dependent　lipid　peroxidation.　Ferroptosis　is　currently　proposed　as　one　of　the　most　promising　means　of　combating　tumor　resistance.　Nevertheless,　the　problem　of　ferroptosis　resistance　in　certain　cancer　cells　has　been　identified.　This　review　first,　investigates　the　mechanisms　of　ferroptosis　induction　in　cancer　cells.　Next,　the　problem　of　cancer　cell　resistance　to　ferroptosis,　as　well　as　the　underlying　mechanisms　is　discussed.　Recently　discovered　ferroptosis-suppressing　biomarkers　have　been　described.　The　various　types　of　nanoparticles　that　can　induce　ferroptosis　are　also　discussed.　Given　the　ability　of　nanoparticles　to　combine　multiple　agents,　this　review　proposes　nanoparticle-based　ferroptosis　cell　death　as　a　viable　method　of　circumventing　this　resistance.　This　review　suggests　combining　ferroptosis　with　other　forms　of　cell　death,　such　as　apoptosis,　cuproptosis　and　autophagy.　It　also　suggests　combining　ferroptosis　with　immunotherapy.