Ferroptosis　is　an　iron-dependent,　non-apoptotic　form　of　regulated　cell　death　and　has　been　implicated　in　the　occurrence　and　development　of　various　diseases,　including　heart　disease,　nervous　system　diseases　and　cancer.　Ferroptosis　induction　recently　emerged　as　an　attractive　strategy　for　cancer　therapy.　Ferroptosis　has　become　a　potential　target　for　intervention　in　these　diseases　or　injuries　in　relevant　preclinical　models.　This　review　summarizes　recent　progress　on　the　mechanisms　of　ferroptosis　resistance　in　cancer,　highlights　redox　status　and　metabolism＇s　role　in　it.　Combination　therapy　for　ferroptosis　has　great　potential　in　cancer　treatment,　especially　malignant　tumors　that　are　resistant　to　conventional　therapies.　This　review　will　lead　us　to　have　a　comprehensive　understanding　of　the　future　exploration　of　ferroptosis　and　cancer　therapy.　A　deeper　understanding　of　the　relationship　between　ferroptosis　resistance　and　metabolism　reprogramming　may　provide　new　strategies　for　tumor　treatment　and　drug　development　based　on　ferroptosis.　©　2023　Elsevier　Inc.